THE PRINCIPLE OF THE TREATMENT

First Riboflavin droplets are applied to the cornea, after which they permeate to the deeper layers of the cornea.

Then UV light is applied, upon which a bonding occurs in the cornea among the collagen fibres (cross-linking). This makes the cornea three (3) times stronger. The process stabilises after six months.

Up to now this procedure took more than one hour (30 minutes for the droplets and 30 minutes for the UV light). But thanks to AVEDRO technology, treatment time is reduced to a maximum of 20 minutes for the droplets phase and a maximum of four (4) minutes for UV exposure. This is primarily due to changes in product composition and a greater energy output for the UV source.

An additional advantage is that the therapy can be conducted on a trans-epithelial level so that there is no post-operative pain. The refractive problems caused by keratoconus (myopia –irregular astigmatism) are often treated beforehand with a topography guided Excimer laser or afterwards with a toric phakic intraocular lens implant.

Ultraviolet Crosslink behandeling met topografische beeld

CASES WHERE RECOMMENDED
  • preventing the development of keratoconus (KC)
  • treating the evolution of keratoconus (progressive form)
  •  ectasia of the cornea
  •  instability of the cornea after a radial keratotomy (RK)
  •  chronic corneal oedema
  •  persistent corneal ulcer
  •  recurrent KC after corneal transplant
RISK FACTORS
  • slower healing process
  • aberrations in healing  (a complication markedly lower with the trans-epithelial approach of the AVEDRO therapy)
  • post-operative infection

CASES WHERE RECOMMENDED

  • corneal thickness of <325µm
  • problems with epithelial healing
  •  herpes keratitis
  • pregnancy